Publication date: 2018-04-21 09:54
Studies have shown that, unlike endogenous progesterone, DMPA has an affinity not only for the progesterone receptor, but also the glucocorticoid receptor (GR) and the androgen receptor. ii MPA has been found to mediate the upregulation or downregulation of various pro-inflammatory and anti-inflammatory cytokines and chemokines through, as some studies have found, MPA’s affinity for the GR. iii
DMPA is an artificial steroid made to mimic the effects of natural endogenous progesterone, a hormone that helps regulate the menstrual cycle and is crucial during pregnancy for the health of the fetus. One of the effects of progesterone is to attenuate the immune system’s inflammatory response to allow the body to accept the embryo during pregnancy. This attenuation of the immune system could also make it easier for the HIV virus to cause an infection.
The use of Depo-Provera Sterile Aqueous Suspension may, due to its cortisol-like glucocorticoid activity, also produce Cushingoid symptoms such as weight gain, edema/fluid retention, and facial swelling.
These are not all the possible side effects of Depo-Provera CI. For more information, ask your healthcare provider or pharmacist.
Prices for the injections alone vary, but the typical cost for each injection can range between $85 and $75. The total cost for a full year of use may vary from $755 to $655 and may vary if additional office visits are required.
You can start using the birth control shot whenever you want. If you get your first shot within the first 7 days after the start of your period, you’re protected from pregnancy right away. If you get it at any other time in your cycle, you need to use another form of birth control (like a condom) for the first week after getting the shot.
Medroxyprogesterone will not protect you from sexually transmitted diseases--including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases.
Depo-Provera (medroxyprogesterone acetate) is a form of birth control. It is an injection, or shot, that contains progestin. This is a natural hormone that your ovaries produce each month as part of your menstrual cycle. You must get it from your primary care or women’s doctor. They give you the injection in either your upper arm or buttock. It can go into a muscle (intramuscular) or under your skin (subcutaneous).
Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.